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Published on: Dec 17, 2018

NIH recently provided updated information for 2019 submissions.

First is the announcement of changes to R01, R03, and R21 Parent Announcements which can be found on the NIH website at

Beginning 01/05/2019:

Activity Code(s) Title Announcement Number
R01 Clinical Trial Required PA-19-055
R01 Clinical Trail not allowed PA-19-056
R03 Clinical Trial not allowed PA-19-052
R21 Clinical Trial Required PA-19-054
R21 Clinical Trial not allowed PA-19-053

If you are submitting an application in 2019 you will want to familiarize yourself with some changes to the instructions and review criteria which can be found in the announcement at

Second, for due dates on or after January 25, 2019, updates include changes to:

  • The rigor of the prior research, formerly Scientific Premise
  • Inclusion reporting
  • Protections for human subjects

Summary of Updates – please refer to the full notice for additional information.

Revisions to the application guide ( are now available.


News Topics: NIHFunding