Noll Physiological Research Seminar Series

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 “Osteosarcopenia: A Geroscience Approach” Gustavo Duque, MD, PhD, FRACP, FGSA, Dr. Joseph Kaufmann Chair in Geriatric Medicine, Faculty of Medicine and Health Sciences, McGill University, Principal Investigator - Bone, Muscle, and Geroscience Group - Research Institute of the McGill University Health Centre, Director - The Simone Edouard Schouela RUISSS McGill Centre of Excellence for Sustainable Health of Seniors (Schouela CEDurable), Editor-in-Chief Journal of Gerontology Biological Sciences
 

Abstract: In older adults, the combination of osteopenia/osteoporosis and sarcopenia—referred to as osteosarcopenia—has been recognized as a condition that increases the risk of adverse health outcomes. The development of osteosarcopenia stems from a complex interaction between bone, muscle, and fat, influenced by genetic, mechanical, and biochemical factors. A sophisticated communication network exists between muscle and bone, with fat now recognized as a disturbing participant. This system includes signaling molecules such as osteokines, myokines, and adipokines, as well as other factors like extracellular vesicles, exosomes, and microRNAs, all of which can positively or negatively impact muscle and bone metabolism and function. These influences contribute to many of the key aspects of aging, often exacerbated by factors like sedentary behavior, obesity, malnutrition, inflammation, and menopause, leading to tissue loss and dysfunction. On the other hand, anabolic processes can be activated to preserve muscle and bone mass and function. Therefore, osteosarcopenia offers an ideal opportunity for geroscience-based interventions to address multiple aging processes, providing dual benefits for both muscle and bone health. This session will explore the shared biological features of osteosarcopenia in muscle and bone, their role in the condition's development, and their potential as therapeutic targets.

For more information contact Professor Gustavo Nader, gan11@psu.edu.